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Influence of Dexmedetomidine on the Human Glymphatic Cerebrospinal Fluid Flow, Neural Activity and Cerebral Blood Flow in Functional Magnetic Resonance Imaging (GlymphDex)
EU CTIS ID: 2023-507215-35-00
What this study is testing
The aim of this study is to characterize brain pulsations, blood flow, and cerebrospinal fluid flow using functional MRI in different states of consciousness and couple these to neural activity in electroencephalography in the awake brain and under different levels of dexmedetomidine sedation.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Fluent Finnish skills
- Head circumference max 59 cm
- Right-handedness
- Age 18-45 years
- Healthy
- Normal baseline ECG
You likely can't join if
- Previous history of intolerance to the study drug or related compound/additive
- Blood donation within 3 months prior to and during the study
- Known history of snoring or obstructive sleep apnea
- Chronic sleep disturbance
- Previous or present alcoholism or drug abuse or tendency to drug or alcohol abuse
- Low body weight (< 50 kg) or BMI < 18.5 kg/m2 or BMI > 30 kg/m2
See the full eligibility criteria
- Fluent Finnish skills
- Head circumference max 59 cm
- Right-handedness
- Age 18-45 years
- Healthy
- Normal baseline ECG
- Normal blood pressure
- Normal SpO2
- No signs of substance abuse
- Acceptable values in laboratory tests
- Normal weight (BMI 18.5-30 kg/m2)
- Previous history of intolerance to the study drug or related compound/additive
- Blood donation within 3 months prior to and during the study
- Known history of snoring or obstructive sleep apnea
- Chronic sleep disturbance
- Previous or present alcoholism or drug abuse or tendency to drug or alcohol abuse
- Low body weight (< 50 kg) or BMI < 18.5 kg/m2 or BMI > 30 kg/m2
- Smoking during one month before the study or during the study
- Inability or difficulty of lying or sleeping in horizontal supine position
- Forearm veins evaluated difficult to cannulate
- Any contraindication to MRI
- Tinnitus or hearing impairment
- Strong susceptibility to allergic reactions
- Known history of significant anaesthetic complication
- Strong susceptibility to nausea
- Airway management is evaluated difficult
- Gastroesofageal reflux
- Pregnancy, planned pregnancy, or lactation
- Existing regular medication (incl contraception)
- Participation in any other clinical study involving investigational or marketed drug products concomitantly or within 3 months prior to entry to this study
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.