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Phase II randomized study evaluating a Pragmatic approach to Adoptive Cell Therapy (ACT) using an IL2 analog (ANV419/ANV600) vs High dose IL2 after Tumor Infiltrating Lymphocytes (TIL) Therapy in patients with melanoma, NSCLC and cervical cancer. The PragmaTIL
EU CTIS ID: 2023-506400-99-00
What this study is testing
- To determine whether TIL-ACT using the IL-2 analog ANV600 reduces the number of predefined grade ≥3 relevant adverse events related to interleukin use (based on Common Terminology Criteria for Adverse Events v5.0 - CTCAE v5.0) compared to TIL-ACT using HD-IL-2. - To determine whether TIL-ACT using the IL-2 analog ANV600 improves patient´s reported outcomes (PRO) (based on selected PRO-CTCAE) compared to TIL-ACT using HD-IL-2.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Patients must have histologically or cytologically proven metastatic or unresectable cutaneous melanoma, NSCLC, or cervical cancer. The disease must have progressed to at least one standard systemic anticancer therapy, whether administered in the adjuvant or metastatic setting, or the patient must be unable or unwilling to receive standard therapy. Patients who are receiving an anticancer treatment post-progression are also eligible to be included, at the Investigator’s discretion, always respecting the wash-out period for starting NMA-LD chemotherapy
- Patients with documented FEV1, FVC and DLCO ≥50% tested by a pulmonary function test.
- Patients must be seronegative for HIV antibody (patients who are HIV seropositive may be less responsive and more susceptible to toxicities related to this experimental treatment since they may have a decreased immune competence).
- Patients must be seronegative for active hepatitis B (defined as having a negative hepatitis B surface antigen [HBsAg] test), and seronegative for hepatitis C antibody. Patients with a history of hepatitis B virus (HBV) infection and having a negative HBsAg test and a positive antibody to hepatitis B surface antigen (HBsAg) are eligible. Patients with the hepatitis C antibody test positive are eligible only if tested for the presence of antigen by RT-PCR and be HCV RNA negative.
- Life expectancy ≥3 months.
- Patients who are of childbearing potential (postmenarcheal who has not reached a postmenopausal state and has not undergone surgical sterilization) or have partners of childbearing potential must agree to use a highly effective method of contraception during the study and for at least 6 months after the last dose of IL-2.
You likely can't join if
- Patients with more than two brain metastases. Note: Patients with brain metastases > 1cm in diameter or perilesional edema on MRI scan must be definitively-treated and stable for at least 4 weeks, and the patient must not require corticosteroid treatment >10 mg prednisone or equivalent per day to be considered for enrollment;
- Patients requiring regular treatment with steroids at a dose higher than prednisone 10 mg/day (or equivalent). Note: use of inhaled, topical steroids and use of systemic physiologic corticosteroid replacement therapy are permitted.
- Patients with current or history within the last 6 months, as determined by the Investigator, of clinically significant, progressive, and/or uncontrolled renal, hepatic, hematological, endocrine, pulmonary, cardiac, gastroenterological or neurological disease.
- Patients with a history of coronary revascularization or ischemic symptoms within 6 months of first dose of NMA-LD chemotherapy.
- History of idiopathic pulmonary fibrosis or evidence of active pneumonitis (any origin).
- Patients with allergies to any of the compounds included in any of the treatment products.
See the full eligibility criteria
Who can join
- Patients must have histologically or cytologically proven metastatic or unresectable cutaneous melanoma, NSCLC, or cervical cancer. The disease must have progressed to at least one standard systemic anticancer therapy, whether administered in the adjuvant or metastatic setting, or the patient must be unable or unwilling to receive standard therapy. Patients who are receiving an anticancer treatment post-progression are also eligible to be included, at the Investigator’s discretion, always respecting the wash-out period for starting NMA-LD chemotherapy
- Patients with documented FEV1, FVC and DLCO ≥50% tested by a pulmonary function test.
- Patients must be seronegative for HIV antibody (patients who are HIV seropositive may be less responsive and more susceptible to toxicities related to this experimental treatment since they may have a decreased immune competence).
- Patients must be seronegative for active hepatitis B (defined as having a negative hepatitis B surface antigen [HBsAg] test), and seronegative for hepatitis C antibody. Patients with a history of hepatitis B virus (HBV) infection and having a negative HBsAg test and a positive antibody to hepatitis B surface antigen (HBsAg) are eligible. Patients with the hepatitis C antibody test positive are eligible only if tested for the presence of antigen by RT-PCR and be HCV RNA negative.
- Life expectancy ≥3 months.
- Patients who are of childbearing potential (postmenarcheal who has not reached a postmenopausal state and has not undergone surgical sterilization) or have partners of childbearing potential must agree to use a highly effective method of contraception during the study and for at least 6 months after the last dose of IL-2.
- Female participants: a female participant is eligible to participate if she is not pregnant, not breastfeeding, and at least one of the following conditions applies: a) Women of non-childbearing potential (WONCBP). b) Women of childbearing potential (WOCBP), who: i. Agree to remain abstinent (refrain from heterosexual intercourse) or use contraceptive methods that result in a failure rate of <1% per year from screening until 6 months after the infusion of the TIL product. Examples of contraceptive methods with a failure rate of <1% per year include bilateral tubal occlusion, male sterilization, and copper intrauterine devices. ii. Have a negative pregnancy test (blood) within one week before the first study treatment administration (applicable to premenopausal women and women ≤2 years after the start of menopause (menopause is defined as amenorrhea for <2 years). iii. Refrain from donating ovules during the study
- Male Participants: during the treatment period and for at least 2 months after the last dose of study treatment, agreement to: a) Remain abstinent (refrain from heterosexual intercourse) or use contraceptive measures such as a condom or a contraceptive method that result in a failure rate of <1% per year, with partners who are WOCBP. b) Refrain from donating sperm during the study. c) Inform if his partner gets pregnant during this time.
- Any toxicity related to prior systemic therapy must have recovered to grade 1 or less according to NCI-CTCAE v5.0 at least 4 weeks before enrollment, except for alopecia, vitiligo, or endocrinopathy managed with replacement therapy, and Grade ≤2 peripheral neuropathy. Note: Other Grade 2 or 3 AEs that are deemed clinically insignificant by treating physician and in consultation with Medical Monitor are permitted.
- Patients may have undergone minor surgical procedures within the past 3 weeks, as long as all toxicities have recovered to grade 1 or less.
- Patients must have at least one adequate lesion (primary tumor or metastasis) for resection or biopsy (with minimal morbidity, preferentially using imaging-guided minimally invasive procedures) for TIL generation. Note: If this lesion was previously irradiated, the lesion must have demonstrated progression prior to resection/biopsy.
- Patients must have a remaining measurable disease as defined by RECIST v. 1.1 criteria following tumor resection/biopsy for TIL manufacturing. Note: Lesions previously irradiated should not be selected as target lesions unless there has been demonstrated progression in those lesions.
- Patients must be at least 18 years old at the tissue procurement visit.
- Patients must understand and voluntarily sign an informed consent document before any study-related assessments/procedures being conducted.
- Patients must be able and willing to comply with the study visit schedule and protocol requirements.
- Patients must have a clinical performance of Eastern Cooperative Oncology Group 0 or 1.
- Patients are considered medically fit enough to undergo all study procedures and interventions and adequate hematological, renal, and hepatic functions defined by: a. Haemoglobin ≥9.0 g/dL. b. An absolute neutrophil count ≥ 1.5x10E9/L without the support of filgrastim. c. Platelets ≥100x10E9/L. d. PT and aPTT ≤1.5 x ULN (unless receiving therapeutic anticoagulation). Patients receiving therapeutic anticoagulation (such as low-molecular-weight heparin or warfarin) should be on a stable dose. e. AST or ALT ≤3 x ULN. Patients with liver metastases must have AST and ALT ≤5.0 x ULN. f. Total bilirubin <2 mg/dL. Patients with Gilbert’s Syndrome must have a total bilirubin ≤3.0 mg/dL. g. Serum creatinine <1.5 mg/dL or measured creatinine clearance ≥50 mL/min calculated using the Cockcroft-Gault glomerular filtration rate estimation: (140 − age) × (weight in kg) × (0.85 if female)/72 × (serum creatinine in mg/dL).
- Patients with documented LVEF of ≥45%.
What rules you out
- Patients with more than two brain metastases. Note: Patients with brain metastases > 1cm in diameter or perilesional edema on MRI scan must be definitively-treated and stable for at least 4 weeks, and the patient must not require corticosteroid treatment >10 mg prednisone or equivalent per day to be considered for enrollment;
- Patients requiring regular treatment with steroids at a dose higher than prednisone 10 mg/day (or equivalent). Note: use of inhaled, topical steroids and use of systemic physiologic corticosteroid replacement therapy are permitted.
- Patients with current or history within the last 6 months, as determined by the Investigator, of clinically significant, progressive, and/or uncontrolled renal, hepatic, hematological, endocrine, pulmonary, cardiac, gastroenterological or neurological disease.
- Patients with a history of coronary revascularization or ischemic symptoms within 6 months of first dose of NMA-LD chemotherapy.
- History of idiopathic pulmonary fibrosis or evidence of active pneumonitis (any origin).
- Patients with allergies to any of the compounds included in any of the treatment products.
- Patients with contraindications for cyclophosphamide, fludarabine and IL-2 at per protocol doses (see SmPC for details).
- Patients who have received any approved anti-cancer cytotoxic, anti-angiogenic and ICB therapy including radiotherapy within 4 weeks before preparative lymphodepleting therapy. a) Exception: palliative radiotherapy for bone metastasis >2 weeks before preparative lymphodepleting therapy, denosumab, bisphosphonates, androgen-deprivation therapy for prostate cancer and hormonal therapy for breast cancer.
- Patients who have received any non-cytotoxic drug and molecular targeted therapy within 4 weeks before preparative lymphodepleting therapy (or within five half-lives of the investigational product, whichever is shorter).
- Patients who have received any investigational agent within 4 weeks before preparative lymphodepleting therapy (or within five half-lives of the investigational product, whichever is shorter).
- Patients who have received a live, attenuated vaccination within the 4 weeks before lymphodepleting therapy.
- Patients with symptomatic brain metastasis.
- Patients who have undergone major surgery in the previous 3 weeks before lymphodepleting therapy.
- Patients who have previously received any investigational cell or gene therapies.
- Women of childbearing potential who are pregnant or breastfeeding.
- Presence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial.
- Patients with leptomeningeal carcinomatosis.
- Patients with an active concurrent or history within the past 3 years of invasive malignancy, except for non-melanoma skin cancer, cervical and bladder carcinoma in situ, good prognosis ductal carcinoma in situ of the breast, or prostate carcinoma that is in remission under androgen deprivation therapy for >2 years. Other exceptions may apply and require discussion between the Investigator and the Medical Monitor.
- Patients with an active systemic infection requiring anti-infective treatment within 14 days before preparative lymphodepleting therapy.
- Patients with active hepatitis B or hepatitis C.
- Patients with active autoimmune disease requiring immunosuppressive treatments.
- Patients with a history of organ or bone marrow transplantation.
- Patients with any form of primary immunodeficiency (such as Severe Combined Immunodeficiency Disease and AIDS).
The study team makes the final eligibility decision.
Where it's taking place
- Israel
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Israel. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.