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A geroscience approach to post-acute COVID-19 syndrome (PACS) by Diet and Exercise plus rapamycin or metformin to treat Frailty and restore immune functions: a randomized, single center clinical trial.
EU CTIS ID: 2023-504641-32-00
What this study is testing
The AIM 1 of the project is to compare two years lifestyles intervention alone or in association with metformin or rapamycin pulse therapy in changing aging trajectories depicted by by an improvement of physical performance assessed by SPPB score as continous variable in people with PACS.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Confirmed PACS diagnosis according to WHO definition by two consecutive clinical assessment
- Previous hospital admission for Severe COVID Pneumonia
- Age 40-80 years
- Frailty or pre-frailty status performed with frailty phenotype criteria
- Independently mobile
- Able and willing to provide written consent.
You likely can't join if
- Previous or current use of metformin
- Diabetes history or diagnosis at baseline
- Transplant or cancer requiring chemotherapy
- History of chronic kidney disease (eGFR<30 mil/min)
- Allergies to metformin or rapamycin
- Female participant pregnant or breastfeeding
See the full eligibility criteria
- Confirmed PACS diagnosis according to WHO definition by two consecutive clinical assessment
- Previous hospital admission for Severe COVID Pneumonia
- Age 40-80 years
- Frailty or pre-frailty status performed with frailty phenotype criteria
- Independently mobile
- Able and willing to provide written consent.
- Previous or current use of metformin
- Diabetes history or diagnosis at baseline
- Transplant or cancer requiring chemotherapy
- History of chronic kidney disease (eGFR<30 mil/min)
- Allergies to metformin or rapamycin
- Female participant pregnant or breastfeeding
- Baseline SPPB score <3
- Life expectancy <6 months
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.