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Using live vaccines to induce beneficial innate immune training and reduce systemic inflammation in COPD patients
EU CTIS ID: 2023-504519-34-01
What this study is testing
To characterize the changes in the innate immune system of COPD patients upon vaccination with live vaccines and determine if vaccination induces trained immunity as reported previously in other populations.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Must have specialist verified, spirometry-confirmed, COPD.
- Age > 40 years
- Able to give informed consent
You likely can't join if
- Acute febrile ilness
- Oral or intravenous corticosteroid at a dose ≥10 mg/day over 3 months
- Cardiac arythmia
- Blood dyscrasia
- Known allergy to either the BCG or MMR vaccines or severe adverse effects during prior vaccination.
- Allergy to MMR vaccine components, neomycin or egg proteins.
See the full eligibility criteria
- Must have specialist verified, spirometry-confirmed, COPD.
- Age > 40 years
- Able to give informed consent
- Acute febrile ilness
- Oral or intravenous corticosteroid at a dose ≥10 mg/day over 3 months
- Cardiac arythmia
- Blood dyscrasia
- Known allergy to either the BCG or MMR vaccines or severe adverse effects during prior vaccination.
- Allergy to MMR vaccine components, neomycin or egg proteins.
- Known prior, active or latent infection with mycobacterium tuberculosis.
- Pregnancy or breastfeeding
- Vaccination with a live vaccine within 4 weeks
- Severe immunocompromisation (HIV-1 infection, organ- or bone marrow transplantation, chemotherapy, primary immune defect, anti-cytokine therapy, immunosuppressant treatment).
- Active solid or non-solid malignancy or lymphona within 2 years, excluding basal cell carcinoma
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.