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Mifepristone and Letrozole in Ectopic Pregnancy (MILE)
EU CTIS ID: 2023-503935-16-00
What this study is testing
To evaluate if the combination of mifepristone and letrozole is non-inferior to methotrexate in treating ectopic pregnancy within a non-inferiority margin of 10%.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Confirmed ectopic pregnancy, or high suspicion thereof*, in need of treatment. *i.e. empty uterus, pathological hCG dynamic.
- 18 years old or above
- Able to understand verbal and written patient information
- Given written consent to participate in the trial
You likely can't join if
- hCG-levels >5000 IU/L
- Heterogenous adnexal mass >35mm
- Fetal heart pulsation
- Signs of rupture such as large amount of free fluid in the abdomen, severe abdominal pain or hemodynamically unstable
- Heterotopic or atypical (cesarean scar pregnancy, cornual, intramural, cervical or abdominal pregnancy) extrauterine pregnancy
- Contraindications* to methotrexate, letrozole or mifepristone. * Allergy, severe liver disease (ALT/AST doubled, kidney disease (GFR <60ml/min), bone marrow suppression, active ulcer, severe stomatitis, breastfeeding, severe infection, chronic adrenal insufficiency, porphyria, uncontrolled asthma, active cancer treatment, ongoing treatment for psychosis, anticoagulants, high alcohol consumption
The study team makes the final eligibility decision.
Where it's taking place
- Thailand
- Nepal
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18-64 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Thailand; Nepal. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.