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Preventing caRdiovascular collapsE with VasoprEssors duriNg Tracheal IntubatiON: The PREVENTION Randomized Controlled Trial (PREVENTION trial)
EU CTIS ID: 2023-503895-25-00
What this study is testing
To determine the potential for pre-emptive vasopressor therapy to reduce the rate of cardiovascular collapse (composite endpoint) among critically ill adults undergoing endotracheal intubation.
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Planned procedure is in-hospital urgent tracheal intubation and planned operator is a provider expected to routinely perform endotracheal intubation in the participating unit
- Patient has a Critical illness (i.e. life-threatening condition requiring tracheal intubation for cardiorespiratory failure or neurological impairment).
- Administration of sedation (with or without neuromuscular blockade) is planned
- Written informed consent is provided by the patient and/or next-of-kin. If the patient will be unable to receive information and no next-of-kin can be contacted during screening for the trial, patient enrollment will be completed as an emergency procedure by the ICU physician, according to local national legislation.
- Planned operator is a provider expected to routinely perform endotracheal intubation in the participating unit
You likely can't join if
- Vasopressors/inotropes at the moment of screening for eligibility.
- Previous enrollment in the PREVENTION trial
- Hypersensitivity to noradrenaline or to any of the excipients.
- MAP < 60 mmHg or > 120 mmHg at the moment of screening for eligibility
- Urgency of intubation precludes safe performance of study procedures
- Cardiac arrest requiring tracheal intubation during cardiopulmonary resuscitation
See the full eligibility criteria
- Planned procedure is in-hospital urgent tracheal intubation and planned operator is a provider expected to routinely perform endotracheal intubation in the participating unit
- Patient has a Critical illness (i.e. life-threatening condition requiring tracheal intubation for cardiorespiratory failure or neurological impairment).
- Administration of sedation (with or without neuromuscular blockade) is planned
- Written informed consent is provided by the patient and/or next-of-kin. If the patient will be unable to receive information and no next-of-kin can be contacted during screening for the trial, patient enrollment will be completed as an emergency procedure by the ICU physician, according to local national legislation.
- Planned operator is a provider expected to routinely perform endotracheal intubation in the participating unit
- Vasopressors/inotropes at the moment of screening for eligibility.
- Previous enrollment in the PREVENTION trial
- Hypersensitivity to noradrenaline or to any of the excipients.
- MAP < 60 mmHg or > 120 mmHg at the moment of screening for eligibility
- Urgency of intubation precludes safe performance of study procedures
- Cardiac arrest requiring tracheal intubation during cardiopulmonary resuscitation
- Enrolled in another clinical trial that is unapproved for co-enrolment
- Known or suspected pregnancy based upon patient information.
- Age less than 18 years.
- Active brain injury with clinical suspicion of elevated intracranial pressure.
- Patient not affiliated to any health insurance system, according to local national legislation
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.