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ASSESSMENT OF THE BRAIN DEPOSIT OF TAU 4R DETECTED BY BRAIN PET WITH 18F-PI2620 IN PROGRESSIVE SUPRANUCLEAR PALSY COMPARED TO CONTROLS WITHOUT NEURODEGENERATIVE TAUOPATHY 4R: A CLINICAL TRIAL
EU CTIS ID: 2023-503538-37-00
What this study is testing
To compare the brain deposit of tau 4R protein by means of the PET-Tau imaging study using the 18F-PI2620 radiotracer in patients with PSP compared to controls.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Subjects from one of the following two groups: a) Patients aged between 40 and 79 years, with a clinical diagnosis of different variants of PSP. Clinical diagnosis will be based on the MDS-PSP criteria for PSP subtypes (Höglinger et al., 2017). In addition, we will apply the recently proposed Multiple Allocations eXtinction (MAX) rules to approach ambiguous multiple allocations (Grimm et al., 2019). b) Control group: b.1.. Patients aged 40 to 79 years, with a clinical diagnosis of PD according to the UK Parkinson's Disease Society Brain Bank Diagnostic Criteria (Hughes et al., 1992) and normal cognitive status (MoCA>24). b.2.. Healthy subjects (male or female) aged 40 to 79 years, with normal neurological examination and normal cognitive status (MoCA>24).
- The subject, or their representative, has given their consent to participate in the study.
- The subject must, in the opinion of the investigator, be able to meet all the requirements of the clinical trial.
You likely can't join if
- Patients with evidence of relevant structural brain abnormalities or significant leukoencephalopathy on magnetic resonance imaging (MRI) (Fazekas score ≥3 or a score of ≥3 on the age-related white matter changes Rating Scale) (Wahlund et al., 2001).
- Patients with PD with cognitive impairment (MoCA<24).
- Pregnant, breastfeeding or childbearing women who are not going to use contraception.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.