BridgeMD
TREASURE trial
EU CTIS ID: 2022-503135-33-00
What this study is testing
The main-objective is to evaluate the effect of an angiotensin-converting-enzyme (ACE) inhibitor compared to care as usual (i.e. no medication) during a two-year open-labeled treatment period in women with asymptomatic heart failure (HF) on reversibility of aberrant cardiac remodeling in asymptomatic HF towards healthy values.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Women, aged 18 years and older
- Heart failure stage-B or diastolic dysfunction
- Premenopausal, with or without a history of preeclamptic pregnancy
- ≥½ and ≤ 30 years after the (first) (complicated) pregnancy;
- Last delivery at least 6 months ago
You likely can't join if
- Already using antihypertensive medication
- Systolic blood pressure of ≥180 mmHg and/or diastolic blood pressure of ≥110 mmHg
- Suffering diabetes mellitus, kidney failure (GFR<60 ml/min/1.73m2), pre-existent auto-immune disease and/or liver insufficiency
- Women have the intention to pursue pregnancy within 2 years (as ACE inhibitors may be teratogenic)
- Breastfeeding during participation
- Auto-immune disease(s) prior to the (complicated) pregnancy
See the full eligibility criteria
- Women, aged 18 years and older
- Heart failure stage-B or diastolic dysfunction
- Premenopausal, with or without a history of preeclamptic pregnancy
- ≥½ and ≤ 30 years after the (first) (complicated) pregnancy;
- Last delivery at least 6 months ago
- Already using antihypertensive medication
- Systolic blood pressure of ≥180 mmHg and/or diastolic blood pressure of ≥110 mmHg
- Suffering diabetes mellitus, kidney failure (GFR<60 ml/min/1.73m2), pre-existent auto-immune disease and/or liver insufficiency
- Women have the intention to pursue pregnancy within 2 years (as ACE inhibitors may be teratogenic)
- Breastfeeding during participation
- Auto-immune disease(s) prior to the (complicated) pregnancy
- Chronic hypertension prior to the complicated pregnancy
- Women who do not want themselves and/or their general practitioner and specialist(s) to be informed about the test results
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.