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Hyperpolarized 129-Xenon MRI in Fibrosing Interstitial Lung Disease
EU CTIS ID: 2022-502512-36-00
What this study is testing
This project aims to investigate the potential of non-invasive imaging to identify and monitor the earliest signs and physiological effects of pulmonary fibrosis and resulting cardiac dysfunction in patients with fibrosing interstitial lung disease. Second, to evaluate baseline risk factors the progression and therapeutic responses to anti-fibrotic drugs.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Patients diagnosed with IPF or fibrotic ILD who fulfills PPF criteria, and are prescribed antifibrotic treatment.
- Age 18-90
- Cognitively able to understand and participate in the study
- Pre-menopausal women must be confirmed non-pregnant by an onsite test.
You likely can't join if
- Contraindications for MRI (Pacemaker, neurostimulator or cochlear implant; Metal foreign bodies such as fragments and irremovable piercings; Unsafe medical implants (safety of heart valves, hips and the like must be confirmed); Intrathoracic clips or coils; Cardiac pacemakers; Claustrophobia; Largest circumference including arms > 160 cm)
- Contraindications to gadolinium contrast (eGFR < 30 mL/min/1.73m2; Previous adverse reactions to gadolinium)
- Overlapping emphysematic disease where the emphysema-component outweighs the fibrosis
- Unable to perform breath-hold of minimum 20 seconds.
- Allergy to Xenon
- Breast feeding
See the full eligibility criteria
- Patients diagnosed with IPF or fibrotic ILD who fulfills PPF criteria, and are prescribed antifibrotic treatment.
- Age 18-90
- Cognitively able to understand and participate in the study
- Pre-menopausal women must be confirmed non-pregnant by an onsite test.
- Contraindications for MRI (Pacemaker, neurostimulator or cochlear implant; Metal foreign bodies such as fragments and irremovable piercings; Unsafe medical implants (safety of heart valves, hips and the like must be confirmed); Intrathoracic clips or coils; Cardiac pacemakers; Claustrophobia; Largest circumference including arms > 160 cm)
- Contraindications to gadolinium contrast (eGFR < 30 mL/min/1.73m2; Previous adverse reactions to gadolinium)
- Overlapping emphysematic disease where the emphysema-component outweighs the fibrosis
- Unable to perform breath-hold of minimum 20 seconds.
- Allergy to Xenon
- Breast feeding
- Evidence of ongoing respiratory infections at time of MR examinations
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.