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Safety of ibuprofen after major orthopaedic surgeries
EU CTIS ID: 2022-502502-32-00
What this study is testing
We aim to assess the beneficial and harmful effects of an eight day postoperative treatment with ibuprofen, a non-selective NSAID and one of the most used non-opioid analgesics, after elective hip and knee arthroplasties.
- Phase III and phase IV (Integrated)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Scheduled for planned primary hip or knee arthroplasty, including hemiarthroplasty.
- Age ≥ 18 years.
- Planned perioperative pain treatment with NSAID, decided by the clinical doctor.
- Negative urine Human Chorionic Gonadotropin (hCG) pregnancy test and use of anti-conception for women in fertile age.
- Written informed consent.
You likely can't join if
- Patients unable to understand or speak Danish.
- Allergy to, or contraindications against ibuprofen, including heart insufficient (NYHA IV), severe thrombocytopenia (< 50 x 10^9/l), asthma triggered by NSAID, or known renal impairment (eGFR < 60 ml/min), previous ulcer due to NSAID treatment.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.