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A Study of Zetomipzomib (KZR-616) in Patients With Active Lupus Nephritis (PALIZADE)
EU CTIS ID: 2022-502227-22-00
What this study is testing
To evaluate the efficacy and safety of zetomipzomib in patients with active Class III or IV (with or without Class V; Class III/IV +/-V) LN and for those with pure Class V LN
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Body mass index of ≥18 kg/m^2 eGFR ≥30 mL/min/1.73 m^2 Unequivocally positive ANA test result and/or a positive anti-dsDNA serum antibody test Diagnosis of LN according to 2003 or 2018 ISN/RPS criteria and confirmed by renal biopsy performed within 12 months prior to Screening. UPCR ≥1.0 (Class III/IV +/-V) or UPCR ≥2.0 (Class V) Adequate hematologic, hepatic, and renal function
You likely can't join if
- 1.Current or medical history of: - Central nervous system manifestations of SLE - Overlapping autoimmune condition that may affect study assessments/outcomes - Antiphospholipid syndrome with history of thromboembolic event of within the 52 weeks prior to Screening - Thrombocytopenia or at high risk for developing clinically significant bleeding or organ dysfunction requiring therapies (i.e., plasmapheresis or acute blood or platelet transfusions - Solid organ transplant or planned transplant during study - Malignancy of any type, with exceptions for non-melanoma skin cancers and certain cancers >5 years ago 2. Has received dialysis within the 52 weeks prior to Screening 3. Positive test at Screening for HIV, hepatitis B/C 4. Known intolerance to MMF or equivalent and corticosteroids
The study team makes the final eligibility decision.
Where it's taking place
- South Africa
- Serbia
- Brazil
- Canada
- Singapore
- Argentina
- Israel
- Taiwan
- Australia
- China
- Turkey
- Colombia
- United States
- United Kingdom
- Korea, Republic of
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include South Africa; Serbia; Brazil; Canada; Singapore; Argentina and 9 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.