BridgeMD
Short or long NAT for BR/LAPC (ADVANTAGE Trial)
EU CTIS ID: 2022-502117-29-00
What this study is testing
To assess the optimal duration of preoperative chemotherapy before conversion surgery for patients with borderline and locally advanced pancreatic ductal adenocarcinoma in attempt to improve survival
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- • Borderline or locally advanced pancreatic adenocarcinoma at diagnosis according to NCCN Clinical Practice Guidelines, version 1.2022 • Histo- or cytologically confirmed adenocarcinoma • T1-4, Nx, M0 according to AJCC 8th edition • Age ≥ 18 years-of-age • ECOG 0-1 and considered fit for the planned chemotherapy and surgery • Written informed patient consent
You likely can't join if
- - Co-morbidity precluding pancreatic surgery or chemotherapy - Sensitivity to any of the drugs in the proposed management regimens - ECOG ≥2 - neuropathy ≥ grade 2 according to Common Terminology Criteria for Adverse Events (CTCAE), version 6 [47] - granulocyte count < 1500 per cubic millimetre (< 1,5 x 109/L) - platelet count < 100 000 per cubic millimetre (< 100 x 109/L) - serum creatinine > 1.5 UNL (upper limit normal range) - albumin <2,5 g/dl (<25 g/L) - total bilirubin >3 x ULN - ASAT (SGOT) and ALAT (SGPT) >2.5 x institutional ULN - female patients in child-bearing age not using adequate contraception, pregnant or lactating women - mental or somatic disorders which could possibly interfere with informed consent, compliance or the planned treatments - previous oncologic treatment for pancreatic adenocarcinoma within the past 5 years - Any reason according to the investigator why the patient cannot comply with the protocol or is not suitable to participate
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.