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Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren Contracture Affecting the Metacarpophalangeal Joint. A Randomized Controlled Trial.
EU CTIS ID: 2022-501549-57-00
What this study is testing
The purpose of this trial is to compare Percutaneous Needle Fasciotomy (PNF) with corticosteroid injection (intervention) and PNF with saline injection (placebo) for Dupuytren Contracture affecting the metacarpophalangeal joint. The primary objective of the study is to investigate if PNF with corticosteroid injection yield better long-term results, defined as reduced recurrence rate (≤20° passive extension deficit) compared with PNF alone
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- >= 45 years
- DC of ≥ 20° passive extension deficit (PED) in MCP joint measured with a finger goniometer
- DC of either II-V finger
- Well-defined/palpable cord
- Received oral and written information of the trial prior to inclusion
- Willingness to participate and signed written informed patient consent form
You likely can't join if
- Legally incapacitated
- Rheumatoid arthritis
- Amyloidosis or mucopolysaccharidosis
- Unable to communicate, cooperate or participate in follow-up
- Unable to speak or read Danish language
- Previous study inclusion with another finger ray
See the full eligibility criteria
- >= 45 years
- DC of ≥ 20° passive extension deficit (PED) in MCP joint measured with a finger goniometer
- DC of either II-V finger
- Well-defined/palpable cord
- Received oral and written information of the trial prior to inclusion
- Willingness to participate and signed written informed patient consent form
- Legally incapacitated
- Rheumatoid arthritis
- Amyloidosis or mucopolysaccharidosis
- Unable to communicate, cooperate or participate in follow-up
- Unable to speak or read Danish language
- Previous study inclusion with another finger ray
- Isolated PIP or DIP joint contracture, defined as MCP joint contracture < 20° PED regardless of the deficit in the PIP or DIP joint
- Previous hand surgery of the affected finger for any reason
- Known allergy to the study medication
- Anticoagulant therapy (Acetylsalicylic acid is NOT an exclusion criterion)
- Pregnant or lactation
- Insulin dependent diabetes mellitus
- Ongoing systemic infection or local infection at the site of the procedure
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.