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"TOPOLOGY" : A phase II study to evaluate the efficacy and toxicities of PLX038, in patients with locally advanced or metastatic triple-negative breast cancer
EU CTIS ID: 2022-501507-27-00
What this study is testing
Efficacy of PLX038 on response rate
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Willing and able to comply with the protocol and provide written informed consent prior to study-specific screening procedures
- Patients whose cancer has a CPS score ≥10 must have received prior pembrolizumab unless (i) contra-indicated (ii) CPS score or pembrolizumab not available at time of first line treatment start
- Resolution of chemotherapy and radiation therapy related toxicities to NCI-CTCAE version 5.0 Grade 1 or lower severity, except for stable sensory neuropathy (≤ Grade 2), alopecia (any grade), presence of clinically managed chronic autoimmune AEs from prior immune therapy
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Adequate organ function (obtained within 14 days prior to treatment start) as evidenced by: i. Absolute neutrophil count (ANC) ≥ 1.5 X 109/L; ii. Hemoglobin (Hgb) ≥ 9 g/dL; iii. Platelet count ≥ 100 X 109/L; iv. Bilirubin ≤ 1.5 X upper limit of normal (ULN), except for patients with a documented history of Gilbert’s disease (≤ 2 X ULN); v. Alanine aminotransferase (ALT), and aspartate aminotransferase (AST) ≤ 2.5 X ULN (for patients with liver metastases ≤ 5 X ULN); vi. Alkaline phosphatase (AP) ≤ 3 X ULN (for patients with liver metastases, ≤ 5 X ULN); vii. Serum creatinine ≤ 1.5 mg/dL (133 μmol/L) or calculated creatinine clearance ≥ 50 mL/min (using Cockcroft-Gault formula); viii. Women of childbearing potential (WCBP): negative serum pregnancy test
- Patients covered by social security or health insurance in compliance with the national legislation relating to biomedical research
You likely can't join if
- Patients who had a last dose of IV chemotherapy within 21 days, last dose of oral cytotoxic chemotherapy, radiotherapy, biological therapy, or investigational therapy within 14 days prior to treatment start
- Severe/uncontrolled intercurrent illness within the previous 28 days prior to inclusion
- Significant known cardiovascular impairment (NYHA CHF > grade 2, unstable angina, myocardial infarction within the previous 6 months prior to inclusion, or existing unstable cardiac arrhythmia)
- Any other significant medical, psychological, social or geographic conditions that in the opinion of the Investigator would impair study participation or cooperation
- Patients deprived of their liberty or under guardianship
- Patients who had any major surgery within 28 days prior to inclusion
See the full eligibility criteria
Who can join
- Willing and able to comply with the protocol and provide written informed consent prior to study-specific screening procedures
- Patients whose cancer has a CPS score ≥10 must have received prior pembrolizumab unless (i) contra-indicated (ii) CPS score or pembrolizumab not available at time of first line treatment start
- Resolution of chemotherapy and radiation therapy related toxicities to NCI-CTCAE version 5.0 Grade 1 or lower severity, except for stable sensory neuropathy (≤ Grade 2), alopecia (any grade), presence of clinically managed chronic autoimmune AEs from prior immune therapy
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Adequate organ function (obtained within 14 days prior to treatment start) as evidenced by: i. Absolute neutrophil count (ANC) ≥ 1.5 X 109/L; ii. Hemoglobin (Hgb) ≥ 9 g/dL; iii. Platelet count ≥ 100 X 109/L; iv. Bilirubin ≤ 1.5 X upper limit of normal (ULN), except for patients with a documented history of Gilbert’s disease (≤ 2 X ULN); v. Alanine aminotransferase (ALT), and aspartate aminotransferase (AST) ≤ 2.5 X ULN (for patients with liver metastases ≤ 5 X ULN); vi. Alkaline phosphatase (AP) ≤ 3 X ULN (for patients with liver metastases, ≤ 5 X ULN); vii. Serum creatinine ≤ 1.5 mg/dL (133 μmol/L) or calculated creatinine clearance ≥ 50 mL/min (using Cockcroft-Gault formula); viii. Women of childbearing potential (WCBP): negative serum pregnancy test
- Patients covered by social security or health insurance in compliance with the national legislation relating to biomedical research
- Age ≥ 18 years
- Females and males with cytologically or histologically confirmed breast carcinoma (either the primary or metastatic lesions)
- Locally advanced or metastatic disease that is not amenable to curative treatment
- Triple negative breast cancer (both ER and PR <10%, HER2-negative or HER2-low)
- Measurable disease (per RECIST version 1.1)
- Prior therapy (administered in the neoadjuvant, adjuvant and/or metastatic setting) with an anthracycline, taxane and sacituzumab-govitecan (unless not medically appropriate or contraindicated for the patient)
- Received a minimum of two prior cytotoxic chemotherapy regimens for locally advanced or metastatic breast cancer
- Patients with known gBRCA mutations must have received a PARP inhibitor in the metastatic setting.
What rules you out
- Patients who had a last dose of IV chemotherapy within 21 days, last dose of oral cytotoxic chemotherapy, radiotherapy, biological therapy, or investigational therapy within 14 days prior to treatment start
- Severe/uncontrolled intercurrent illness within the previous 28 days prior to inclusion
- Significant known cardiovascular impairment (NYHA CHF > grade 2, unstable angina, myocardial infarction within the previous 6 months prior to inclusion, or existing unstable cardiac arrhythmia)
- Any other significant medical, psychological, social or geographic conditions that in the opinion of the Investigator would impair study participation or cooperation
- Patients deprived of their liberty or under guardianship
- Patients who had any major surgery within 28 days prior to inclusion
- Patients with chronic inflammatory bowel disease and/or bowel obstruction
- Concomitant use of other agents for the treatment of cancer or any investigational agent(s)
- Brain metastases, unless local therapy was completed and use of corticosteroids for this indication discontinued for at least 3 weeks prior to inclusion. Signs or symptoms of brain metastases must be stable for at least 28 days prior to inclusion. No known progression of brain metastases (by imaging as assessed by RECIST) can have occurred. Patients with leptomeningeal disease or meningeal carcinomatosis are excluded
- Women who are either pregnant, lactating, planning to get pregnant
- Patients receiving pharmacotherapy for hepatitis B or C, tuberculosis, or HIV
- Patients with known liver disease diagnosed with Child-Pugh A or higher cirrhosis
- Prior stage III or IV malignancy (other than breast cancer)
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.