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Impact of opioids on heart rate during rapid sequence intubation : Double-blind randomized controlled study (CANDY-CRASH).
EU CTIS ID: 2022-501500-10-00
What this study is testing
Assess the impact of opioids on heart rate due to laryngoscopy at the time of intubation in rapid sequence.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Patient over 65 years old and any possible ASA OR Patient aged 55 to 65 years old with an ASA ≥ 3
- Patient undergoing surgery (urgent or scheduled), requiring general anesthesia in rapid sequence, because considered to have a "full stomach", i.e. with: gastro-oesophageal pathology or gastroparesis or a history of bariatric surgery or occlusive syndrome (with or without naso-gastric tube), or failure to respect food <6 hours and/or water <2 hours
- Patient regardless of body mass index (BMI)
- Patient regardless of their orotracheal intubation criteria present during the anesthesia consultation
- Patient informed of the study who gave their written consent before starting the study procedures
- Patient affiliated to a French social security system
You likely can't join if
- Patient < 55 years old
- Patient participating in another interventional clinical research
- Patient under AME (State Medical Aid)
- Patient on beta blockers
- Atrial fibrillation or other rhythm or conduction disturbances
- Patient in hemodynamic failure SBP < 90 mmHg and DBP < 60 mmHg) and/or on catecholamines before the start of GA
See the full eligibility criteria
- Patient over 65 years old and any possible ASA OR Patient aged 55 to 65 years old with an ASA ≥ 3
- Patient undergoing surgery (urgent or scheduled), requiring general anesthesia in rapid sequence, because considered to have a "full stomach", i.e. with: gastro-oesophageal pathology or gastroparesis or a history of bariatric surgery or occlusive syndrome (with or without naso-gastric tube), or failure to respect food <6 hours and/or water <2 hours
- Patient regardless of body mass index (BMI)
- Patient regardless of their orotracheal intubation criteria present during the anesthesia consultation
- Patient informed of the study who gave their written consent before starting the study procedures
- Patient affiliated to a French social security system
- Patient < 55 years old
- Patient participating in another interventional clinical research
- Patient under AME (State Medical Aid)
- Patient on beta blockers
- Atrial fibrillation or other rhythm or conduction disturbances
- Patient in hemodynamic failure SBP < 90 mmHg and DBP < 60 mmHg) and/or on catecholamines before the start of GA
- Patient having a history of stroke, hemorrhagic and/or ischemic and/or transient
- Combination with opioid agonists-antagonists or partial opioid antagonists
- Known hypersensitivity to one of the study drugs or to opioids
- History of difficult intubation
- Patient under guardianship, curatorship or deprived of liberty
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.