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A Study of LY3473329 in Adult Participants With Elevated Lipoprotein(a) at High Risk for Cardiovascular Events ( KRAKEN )
EU CTIS ID: 2022-501466-21-00
What this study is testing
The main purpose of this study is to evaluate the efficacy and safety of LY3473329 in adult participants with elevated Lp(a) at high risk for cardiovascular events.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Participants must be at least 40 years old and have Lp(a) level≥175 nmol/L at screening.
- Have coronary artery disease, stroke or peripheral artery disease, familiar hypercholesterinemia or type 2 diabetes.
- Participants if on the following medications must be on stable regimen before participating and through the end of treatment and assessment period: lipidlowering drugs, testosterone, estrogens, anti-estrogens, progestins, selective estrogen receptor modulators or growth hormone
- A body mass index within the range 18.5 to 40 kilogram/square meter
- Males and female of child bearing potential who agree to use highly effective contraception methods or women not of childbearing age
You likely can't join if
- Had history of underlying disease or surgical, physical medical or psychiatric condition
- Had major surgery within 3 months of randomization
- Had coronary, carotid, or peripheral arteria revascularization, stroke, heart attack or chest pain within 3 months of day 1
- Have uncontrolled diabetes
- Have uncontrolled high blood pressure
The study team makes the final eligibility decision.
Where it's taking place
- Japan
- China
- Mexico
- Australia
- Brazil
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Japan; China; Mexico; Australia; Brazil. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.