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A Four Way Crossover Thorough QT/QTc Study to Evaluate the Electrocardiographic Effects of Therapeutic and Supratherapeutic Doses of Cytisinicline in Healthy Smokers
EU CTIS ID: 2022-500954-40-00
What this study is testing
Assess the effects of cytisinicline at therapeutic and supratherapeutic doses on cardiac repolarization relative to placebo in healthy adult subjects who are smokers.
- Human Pharmacology (Phase I)- Other
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Regular moderate cigarette smokers (minimum 10 cigarettes per day).
- Healthy males and females 18-45 years of age.
- If woman, she meets one of the following criteria: a. is of non-childbearing potential or b. is of childbearing potential and agrees to use an accepted contraceptive method from at least 4 weeks prior to admission to period 1 until at least the last study drug administration.
- No clinically significant abnormal serum chemistry or hematology values at Screening.
- Body mass index (BMI) within 18-30 kg/m2 at Screening.
- Subject must be willing to communicate with the investigator and site staff and comply with all study procedures and requirements.
You likely can't join if
- History or presence of a systemic disease, which as judged by the investigator, may affect the subject’s ability to participate in the study or in the outcome of the study.
- Resting supine pulse rate less than 50 beats per minute or greater than 100 beats per minute at Screening.
- Resting supine systolic blood pressure less than 90 mmHg or greater than 140 mmHg; resting supine diastolic blood pressure less than 50 mmHg or greater than 90 mmHg at Screening.
- Clinically significant ECG abnormalities at Screening, including: a. QTcF >450 ms b. QRS >110 ms c. PR >200 ms d. Second or third-degree AV block e. Any rhythm other than sinus rhythm, which is interpreted by the investigator to be clinically significant
- Renal impairment defined as a creatinine clearance (CrCl) <90 mL/min, based on creatinine clearance calculation by the Cockcroft-Gault formula and normalized to an average surface area of 1.73 m2, at Screening.
- Serum alanine aminotransferase (ALT) or serum aspartate aminotransferase (AST) above the ULN (upper limit of the reference range) at Screening.
See the full eligibility criteria
Who can join
- Regular moderate cigarette smokers (minimum 10 cigarettes per day).
- Healthy males and females 18-45 years of age.
- If woman, she meets one of the following criteria: a. is of non-childbearing potential or b. is of childbearing potential and agrees to use an accepted contraceptive method from at least 4 weeks prior to admission to period 1 until at least the last study drug administration.
- No clinically significant abnormal serum chemistry or hematology values at Screening.
- Body mass index (BMI) within 18-30 kg/m2 at Screening.
- Subject must be willing to communicate with the investigator and site staff and comply with all study procedures and requirements.
- Subject must be able to provide written, informed consent including compliance with the requirements listed in the consent form.
- Subject must be able and willing to swallow whole tablets without breaking, cutting, or chewing.
What rules you out
- History or presence of a systemic disease, which as judged by the investigator, may affect the subject’s ability to participate in the study or in the outcome of the study.
- Resting supine pulse rate less than 50 beats per minute or greater than 100 beats per minute at Screening.
- Resting supine systolic blood pressure less than 90 mmHg or greater than 140 mmHg; resting supine diastolic blood pressure less than 50 mmHg or greater than 90 mmHg at Screening.
- Clinically significant ECG abnormalities at Screening, including: a. QTcF >450 ms b. QRS >110 ms c. PR >200 ms d. Second or third-degree AV block e. Any rhythm other than sinus rhythm, which is interpreted by the investigator to be clinically significant
- Renal impairment defined as a creatinine clearance (CrCl) <90 mL/min, based on creatinine clearance calculation by the Cockcroft-Gault formula and normalized to an average surface area of 1.73 m2, at Screening.
- Serum alanine aminotransferase (ALT) or serum aspartate aminotransferase (AST) above the ULN (upper limit of the reference range) at Screening.
- Positive urine drug and alcohol screen at Screening or Day -1 for each Treatment Period.
- Positive pregnancy test for WOCBP at Screening or Day-1 to each Treatment Period.
- History of significant alcohol abuse, drug abuse, or use of illicit drugs within one year prior to Screening.
- Average weekly alcohol consumption of >14 units for males and >7 units for females within the previous 6 months.
- Average daily consumption of methylxanthines-containing beverages or food (e.g., coffee, tea, cola, sodas, chocolate) equivalent to >500 mg of methylxanthines.
- Evidence of infection with Hepatitis B or C, or human immunodeficiency virus HIV-1 or HIV-2, as determined by results of testing at Screening.
- Subject has donated or lost ≥450 mL of blood within the previous 2 months prior to study drug administration or has donated plasma within 7 days prior to study drug administration.
- Known hypersensitivity/allergy reaction to moxifloxacin or other fluoroquinolones.
- Use of prescription medication within 14 days or 5 half-lives (whichever is longer) or over-the-counter products (including natural food supplements) within 7 days prior to admission to Treatment Period 1, unless in the investigator’s opinion the medication does not interfere with the pharmacokinetics of study drug or compromise subject safety. Exceptions include topical products without systemic absorption, hormonal contraceptives, hormone replacement therapy, and acetaminophen (≤2 g/day).
- Any allergy, intolerance, restriction or special diet that, in the opinion of the investigator, could contraindicate the subject’s participation in this study.
- History of unexplained loss of consciousness, unexplained syncope, unexplained irregular heartbeats or palpitations or near drowning with hospital admission.
- Subjects who received any investigational drug 30 days or 5 half-lives (whichever is longer) prior to first study drug administration.
- Use of other forms of nicotine (e-cigarettes, smokeless tobacco) or are planning to use these products during study.
- Known hypersensitivity/allergy reaction to varenicline, cytisinicline or other cytisinicline-derivatives.
- Positive SARS-CoV-2 test, prior to admission to each study period.
- Any reason which, in the opinion of the investigator, would prevent the subject from participating in the study.
- Female subjects who are pregnant or lactating.
- Family history of QTc prolongation or of unexplainable sudden death at <50 years of age.
- History of QTc prolongation or knowledge of any kind of cardiovascular disorder/condition known to increase the possibility of QT prolongation or history of additional risk factors for Torsade de Pointes (e.g., heart failure, hypokalemia, family history of Long QT Syndrome or Brugada Syndrome) or cardiac conduction disorders.
- History of myocardial infarction, unstable angina pectoris, cerebrovascular disease, atherosclerosis or arterial hypertension.
- History of rare hereditary problem of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
- History of glucose 6-phosphate dehydrogenase deficiency or myasthenia gravis.
- Use of any medication that might interfere with the PK of cytisinicline.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.